A Victorian-era Toronto detective uses then-cutting edge forensic techniques to solve crimes, with the assistance of a female coroner who is also struggling for recognition in the face of tradition, based on the books by Maureen Jennings.
With their lives in danger, Murdoch searches for Anna Fulford and her son in Montreal.
To save his former lover and son, Murdoch makes a risky deal with a Black Hand henchman.
Murdoch pursues Inspector Giles after he escapes from prison to vindicate a murderer.
When their train derails, Ogden and Brackenreid suspect it was sabotage to hide a murder.
When Murdoch investigates the murder of a ladies man, Crabtree’s aunt is the prime suspect.
At Halloween, Murdoch pursues a killer dressed as a clown who is terrorizing romantic, young couples.
To solve an inmate's murder, Murdoch sends Ogden undercover at a woman's reformatory.
While investigating a stabbing, Murdoch and Brackenreid inadvertently discover spy Terrence Meyers' hidden civilian life.
Murdoch investigates when Higgins goes missing while searching for his kidnapped sister-in-law.
Murdoch suspects the murder of a nasty, satirical cartoonist has links to city politics.
Murdoch and company's Christmas at an idyllic country estate turns potentially deadly.
Murdoch investigates the suspicious death of a stage manager after a going away party for Mary Pickford.
When Murdoch investigates the mysterious death of a colleague of Sigmund Freud, he receives unexpected psychoanalysis.
Murdoch arrests a man for trying to kill a woman he claims is a witch, shortly thereafter he dies mysteriously while in custody.
Murdoch's son Harry is visiting from boarding school when William and Julia are abducted by a nefarious, vengeful foe.
A charity basketball game takes a grim turn for Murdoch and his colleagues when a friend of the game's inventor is murdered.
Violet Hart investigates when a protester dies at an event for Black people's rights.
Murdoch investigates when a Japanese spy is found dead in a Korean family's cellar.
Murdoch suspects someone in a vagrant encampment robbed and killed a young woman.
Murdoch investigates after a murder is transmitted over James Pendrick's new invention.
Murdoch investigates the murder of a musician whose death was narrated in a blues song.
When Crabtree's mentally deranged kidnapper, Amelia, turns herself in, he braces for trouble.
When a Murdoch lookalike is murdered, danger is near. Murdoch must find the murder before the murder finds him.
Season Finale: With his family in hiding, Murdoch tries to discover who is behind attempts on their lives.