Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.
The Gang looks back on 2020 to justify their numerous PPE loans. In doing so, it is revealed that they contributed to the chaos of the past political year way more than anyone could have imagined.
Upon discovering that their self-made Lethal Weapon sequels have been pulled from the local library, the Gang decides to address their political incorrectness by making another film — Lethal Weapon 7.
In the past, an innocent Dennis learns the horrifying details of Frank's business, a truly sweet Dee is excited to head off for Hollywood, while Charlie and Mac's jobs at the roller rink are in jeopardy.
When the Gang suspects Dee is menopausal, they scramble to find a new employee for Paddy's Pub. Dee decides to put her acting career on hold in order to mentor young actors.
The gang's in Dublin where Dennis ends up helping Frank with some of his business's dirty work. Mac and Charlie learn about their Irish heritage. Dee rushes to the set of an Irish soap opera, where she will play an "Obnoxious American MILF."
Dennis and Dee explore their new accommodations in the countryside. Frank accompanies Charlie to find the truth about Charlie's Irish childhood pen pal. Mac has an identity crisis and decides to join the seminary.
Mac spends a day at the seminary to truly understand what it takes to become a priest. Dennis and Frank plan an elaborate trap to humiliate Charlie's pen pal. Dee prepares for a date with an Irish doctor. Charlie bonds with his pen pal.
The Gang attempts to ascend a mountain in order for Charlie to fulfill an old and mysterious Irish burial tradition. One by one, the Gang backs out until Charlie is left to honor the dead body alone.