A group of lesbian friends struggle with romance and careers in Los Angeles.
Shane tries to deal with her betrayal to Jenny as they both attempt to figure out their feelings for one another. Shane awkwardly tries to apologize to Jenny, who responds by threatening to evict Shane from her house. Meanwhile, Bette and Tina get worried when Angelica comes down with a fever which gradually gets worse. Alice and Tasha cannot decide whether to break up or stay together since their different views on life strain their romance to the breaking point. Elsewhere, Helena and Kit celebrate after taking over SheBar nightclub and formally rename the place, 'HIT!'
Bette and Tina talk about expanding their family and beginning a new life but the plan could be ruined when Bette bumps into an old friend with dangerous potential; Alice and Tasha ponder their compatibility as they seek counseling; an old flame appears, sending Helena reeling; and Max is faced with an extraordinary situation.
The negative of “Lez Girls” goes missing; Shane’s incessant apologizing to Jenny finally gets noticed; Alice’s feelings are hurt when Jenny denounces her desire to write a screenplay; Phyllis lets Bette in on a suppressed secret; and it’s opening night at Kit and Helena’s new club, HIT!
Shane and Jenny are still melting over each other; Bette and Tina go to Nevada to meet a potential birth mother; Max is trying to deal with being pregnant; Alice and Tasha play matchmaker; and Kelly Wentworth may have what Bette needs.
Jenny writes another script that sells; Bette and Kelly go into business; Alice and Tasha have a third-wheel crush; the girls plot a sting operation to test Dylan; and, Jenny encroaches more on Shane.
Jenny throws a baby shower for Max; Bette and Tina hit a roadblock in the adoption process; Bette goes solo to her gallery’s opening night celebration leading Kelly to go in for the kill; Shane is feeling boxed in by Jenny; and Alice starts to feel like three is a crowd.
The Los Angeles Gay & Lesbian Center dance marathon is on; someone is moving to the Big Apple; rumors fly fast around the dance floor that Alice and Tasha may be in couple trouble; The HIT!’s Sunset Blvd makes a shocking revelation to Kit; and there’s a no-show at the bus station.
In the final episode of the series, what starts out as a celebration of friendship quickly ends in a web of betrayal and deceit; the girls find themselves in the slammer with Sergeant Duffy; and the investigation into ? ? death begins…