The Powerpuff Girls is a animated television series about Blossom, Bubbles, and Buttercup, three kindergarten-aged girls with superpowers, as well as their "father", the brainy scientist Professor Utonium, who all live in the fictional city of Townsville, USA. The girls are frequently called upon by the town's childlike and naive mayor to help fight nearby criminals using their powers.
When the Girls hear the Professor trying to make something out of sugar, spice, and everything nice, they are sure he's trying to create new little girls.
The Mayor keeps having the same dream over and over again, but he never sees the end. Now it's up Girls to go into the Mayor's head and solve this mystery.
When Mojo discovers that the Rowdyruff Boys have returned, he competes with Him to determine who's the more evil father.
One day during a picnic Bubbles get stung in her mouth by a bee. After a visit by the doctor she is forbidden to speak for a week. Suddenly when all the squirrels in Townsville get mad, Blossom and Buttercup are unable to do anything without Bubbles special ability. Now it's up to Bubbles and Bullet to stop this crime.
The Ganggreen Gang is committing brilliant crimes for Sedusa so she can get her revenge on the girls for making her bald.
The girls rescue a baby from a monster and are forced to care for it when they can't find its mother.
Mojo takes over as the narrator. He commands the girls to do what he wants until it's revealed in the end what happened to the narrator.
The girls get bad sunburns.
Lou Gubrious sets a crying ray on Townsville.
Professor Utomium sends the Steamypuff Girls to save the western town of Townsville from Mojo the Kid.
The Powerpuff Girls must literally work as one to try and stop Mojo Jojo from destroying Townsville.
Captain Crack McGraigen and his crew are tossed forward in time.
The Powerpuff Girls and the Professor set on an old-fashioned vacation to the Townsville Swamp. Trouble is, Fuzzy and his nephews are there too.
Twenty stories tall, The Powerpuff Girls spell disaster for Townsville when they delicately try to stop Mojo Jojo from taking over.
Buttercup feels left out when she realizes that she doesn't have any special powers like her sisters.
When a TV show convinces kids to send in money to enter a special contest, Bubbles and the rest of the kids in the neighbor hood raise money to enter it.
A medium named Madame Argentina, and her side-kick, Fred the duck (he really is a duck) attempt to steal money from Townsville's citizens by offering to contact a dead relative for them.
Professor Utonium is hosting a party for all the rich and famous people in Townsville, so Bubbles makes sure that she is the most beautiful of the girls by continually grooming herself. While doing this, she notices one of Octi's legs poking out from under the girls' bed, so she goes to pick him up to find that all that's there is one of Octi's legs! After waking up from the shock, she vows to exact revenge on the person who 'killed' Octi.