After her dentist husband of 20 years leaves her for his dental hygienist, Reba Hart's seemingly perfect world is turned upside down.
After Barbra Jean's successful weight loss, Reba becomes worried that she'll soon become the chubby friend and starts to eat healthy. Meanwhile, Brock is becoming suspicious that Barbra Jean maybe having an affair with her trainer, Jordan, leading him to ask Reba to check out what is really happening at the gym.
The biggest real estate company in town has called and Reba convinces Van to place his loyalty aside and come with her to see what their intentions are only to find out they just want Van and not her. Meanwhile, Brock is worried that Barbra Jean's new look is going to make her look elsewhere so he goes through some interesting changes to impress her.
After Van declines the offer from Norris, he decides to build an office in the Hart's garage for him and Reba to work from. Reba questioning his decision finds out that Cheyenne is pregnant again but was told not to let Cheyenne know he told her. Meanwhile, with only 10 months to college, Kyra decides to move back in with Reba. Reba gets Cheyenne to confess only to also learn that they plan on moving out. Reba is torn emotionally with the return of Kyra and the probable move of Van and Cheyenne.
Reba and a pregnant Cheyenne realize that Kyra had too much freedom at Brock and Barbra Jean's. Meanwhile, Jake finds himself accidentally trying out for the wheelchair basketball team and pretends to be handicap to become their star player.
After constant persuasion, Van accepts the job from Steve Norris. Reba supports his decision to move to a bigger Real Estate firm but refuses to let Van take their client list leading to the ultimate Real Estate battle. Meanwhile, Barbra Jean pursues one of her dreams of becoming a TV News Weather Woman.
In order to keep her unborn baby from ending up like Kyra, Cheyenne tries to redeem good karma by giving back Kyra's 5th birthday party that Cheyenne destroyed years ago. Meanwhile, Cheyenne is driving Van crazy with a 20 page list of things to do before the baby arrives. Reba, as always, is caught in the middle with the challenge of fixing all the family problems.
Brock wants to bring the spark back to his marriage, but he doesn't know what to do so he goes to Reba for advice. Meanwhile, Cheyenne's pregnancy sends her hormones crazy and Kyra films Van's goofiness for You Tube.
Barbra Jean who is training an up and coming weather woman from Oklahoma (Kelly) fears she will soon take her job. At first Reba adores Kelly but when she realizes Kelly is just like Barbra Jean in every way, Reba comes to see that perhaps she hasn't forgiven Barbara Jean like she thought. Meanwhile, finding out they're having a boy, Van and Cheyenne have to find a way to break the promise Cheyenne made when she was younger to name her first son - Brock. In the episode's final scene, Brock, Cheyenne and Van perform a spoof of the three "American Idol" judges.
Reba is ordered to relax in order to bring her blood pressure back down, but that is impossible with Brock living in the garage to avoid fighting with Barbara Jean. His constant lies lead Barbara Jean to believe he's out of town and Reba argues for him to just be honest with his wife; the tension between them reaches an all time high leading them to file for divorce. Meanwhile, Van sees his father in himself as he gets fired for his temperament while coaching Jake's lousy soccer team with Jake being the worse player.
Reba finds Van & Cheyenne their perfect house and when trying to make the deal with the owner realizes it is Cheyenne's enemy from high school. Meanwhile, Brock and Barbra Jean get all dolled up to have a divorce date.
Reba and Brock are shocked when Kyra tells them that she is postponing college to go on tour with her band. Unfortunately, when Reba puts her foot down and tells Kyra that she won't allow her to make this huge mistake, Kyra decides to move out. Meanwhile, Cheyenne and Van can't agree on how to decorate their new house.
While Van and Cheyenne settle into their new home, they realize they have their own "Barbra Jean" who constantly comes over unannounced and uninvited - Reba. Meanwhile, Barbra Jean uses her divorce process with Brock to dramatize at her new news-weatherwoman job as Stormy Clearweather on the newscasts to bring in new fans.
When Van's poor home improvements skills causes a small fire in their home, Reba allows them to stay at her house until they get everything back in order. Meanwhile, Barbra Jean turns down an out of state job promotion to make it work with Brock. With everyone at a happy state in their life; they all realize they had a crazy six years but they made it through because "They're Survivors". This Series Finale of Reba concludes 125 episodes and 6 years of crazy commotion and love.